Recent Publications 

Michelle L. Duquette, Justine Kim, Linda Z. Shi, Michael W. Berns,: LSD1 mediated changes in the local redox environment during the DNA damage response. PLoS One. 2018; 13(8): e0201907. Published online 2018 Aug 10. (Link)

Renat N Khaliullin, Rebecca A Green, Linda Z Shi, J Sebastian Gomez-Cavazos, Michael W Berns, Arshad Desai, and Karen Oegema,: A positive-feedback-based mechanism for constriction rate acceleration during cytokinesis in Caenorhabditis elegans. eLife. 2018; 7: e36073. Published online 2018 Jul 2. (Link)

Aaron Selfridge, Nicholas Hyun, Chai-Chun Chiang, Sol M. Reyna, April M. Weissmiller, Linda Z. Shi, Daryl Preece, William C. Mobley, and Michael W. Berns,: Rat embryonic hippocampus and induced pluripotent stem cell derived cultured neurons recover from laser-induced subaxotomy. Neurophotonics. 2015 Jan; 2(1): 015006.Published online 2015 Feb 13. (Link)

VERONICA GOMEZ-GODINEZ, DARYL PREECE, LINDA SHI, NIMA KHATIBZADEH, DERRICK ROSALES, YIJIA PAN, LIE LEI, YINGXIAO WANG, and MICHAEL W. BERNS,: Laser-Induced Shockwave Paired with FRET: A Method to Study Cell Signaling. Microsc Res Tech. Author manuscript; available in PMC 2015 Dec 10. (Link)

Nicholas Hyun, Linda Z. Shi, Michael W. Berns,: Laser MicrobeamTargeting of Single NerveAxons in CellCulture. Neuronal Cell Death pp 211-226. (Link)

Daryl Preece, Kay W. Chow, Veronica Gomez-Godinez,Kyle Gustafson, Selin Esener, Nicole Ravida, Barbara Durrant, and Michael W. Berns,: Red light improves spermatozoa motility and does not induce oxidative DNA damage. Sci Rep. 2017; 7: 46480. Published online 2017 Apr 20. (Link)

Matthew Ono, Daryl Preece, Michelle L. Duquette, Arthur Forer, and Michael W. Berns,: Mitotic tethers connect sister chromosomes and transmit “cross-polar” force during anaphase A of mitosis in PtK2 cells. Biomed Opt Express. 2017 Oct 1; 8(10): 4310–4315. (Link)

Forer A, Duquette ML, Paliulis LV, Fegaras E, Ono M, Preece D, Berns MW,: Elastic 'tethers' connect separating anaphase chromosomes in a broad range of animal cells. Eur J Cell Biol. 2017 Sep;96(6):504-514. doi: 10.1016/j.ejcb.2017.07.001. Epub 2017 Jul 29. (Link)

Kay W. Chow, Daryl Preece, and Michael W. Berns,: Effect of red light on optically trapped spermatozoa. Biomed Opt Express. 2017 Sep 1; 8(9): 4200–4205. (Link)

Arthur Forer, Rozhan Sheykhani and Michael W. Berns,: Anaphase Chromosomes in Crane-Fly Spermatocytes Treated With Taxol (Paclitaxel) Accelerate When Their Kinetochore Microtubules Are Cut: Evidence for Spindle Matrix Involvement With Spindle Forces. Front Cell Dev Biol. 2018; 6: 77. Published online 2018 Jul 24. doi: 10.3389/fcell.2018.00077. (Link)

Rozhan Sheykhani,Michael Berns, and Arthur Forer,: Elastic Tethers Between Separating AnaphaseChromosomes in Crane-Fly Spermatocytes CoordinateChromosome Movements to the Two Poles. RESEARCH ARTICLECytoskeleton, February 2017 74:91–103 (doi: 10.1002/cm.21347). (Link)

Nima Khatibzadeh,Alexander B. Stilgoe, Ann A. M. Bui, Yesenia Rocha, Gladys M. Cruz, Vince Loke, Linda Z. Shi, Timo A. Nieminen, Halina Rubinsztein-Dunlop, Michael W. Berns,: Determination of motility forces on isolated chromosomes with laser tweezers Scientific Reports, 2014 Oct (Link)

Ibsen S, Shi G, Schutt C, Shi L, Suico KD, Benchimol M, Serra V, Simberg D, Berns M, Esener S.,: The behavior of lipid debris left on cell surfaces from microbubble based ultrasound molecular imaging. Ultrasonics. 2014 Jul 1. (Link)

Alcaraz Silva B, Stambaugh JR, Yokomori K, Shah JV, Berns MW.,: DNA Damage to a single chromosome end delays anaphase onset. J Biol Chem. 2014 Jun 30. (Link)

Wang H, Li Y, Truong LN, Shi LZ, Hwang PY, He J, Do J, Cho MJ, Li H, Negrete A, Shiloach J, Berns MW, Shen B, Chen L, Wu X.,: CtIP maintains stability at common fragile sites and inverted repeats by end resection-independent endonuclease activity. Mol Cell. 2014 Jun 19;54(6):1012-21. (Link)

Spitler R, Berns MW.,: Comparison of laser and diode sources for acceleration of in vitro wound healing by low-level light therapy. J Biomed Opt. 2014 Mar;19(3):38001. (Link)

Kong X, Ball AR Jr, Pham HX, Zeng W, Chen HY, Schmiesing JA, Kim JS, Berns M, Yokomori K.,: Distinct functions of human cohesin-SA1 and cohesin-SA2 in double-strand break repair. Mol Cell Biol. 2014 Feb;34(4):685-98. (Link)

Silva BA, Stambaugh JR, Berns MW.,: Targeting telomere-containing chromosome ends with a near-infrared femtosecond laser to study the activation of the DNA damage response and DNA damage repair pathways. J Biomed Opt. 2013 Sep;18(9). (Link)

Spitler R, Schwappacher R, Wu T, Kong X, Yokomori K, Pilz RB, Boss GR, Berns MW.,: Nitrosyl-cobinamide (NO-Cbi), a new nitric oxide donor, improves wound healing through cGMP/cGMP-dependent protein kinase. Cell Signal. 2013 Dec;25(12):2374-82. (Link)

Truong LN, Li Y, Shi LZ, Hwang PY, He J, Wang H, Razavian N, Berns MW, Wu X.,: Microhomology-mediated End Joining and Homologous Recombination share the initial end resection step to repair DNA double-strand breaks in mammalian cells. Proc Natl Acad Sci U S A. 2013 May 7;110(19):7720-5. (Link)

Chandsawangbhuwana C, Shi LZ, Zhu Q, Berns MW.,: Real-time calcium measurements of live optically trapped microorganisms. J Biophotonics. 2013 Apr 11. [Epub ahead of print] (Link)

Chandsawangbhuwana C, Shi LZ, Zhu Q, Berns MW.,: Purple sea urchin Strongylocentrotus purpuratus gamete manipulation using optical trapping and microfluidics. J Biomed Opt. 2013 Apr;18(4):040501. (Link)

Ferraro-Gideon J, Sheykhani R, Zhu Q, Duquette ML, Berns MW, Forer A.,: Measurements of forces produced by the mitotic spindle using optical tweezers. Mol Biol Cell. 2013 May;24(9):1375-86. (Link)

Sheykhani R, Baker N, Gomez-Godinez V, Liaw LH, Shah J, Berns MW, Forer A.,: The role of actin and myosin in PtK2 spindle length changes induced by laser microbeam irradiations across the spindle. Cytoskeleton (Hoboken). 2013 May;70(5):241-59. (Link)

Wang H, Shi LZ, Wong CC, Han X, Hwang PY, Truong LN, Zhu Q, Shao Z, Chen DJ, Berns MW, Yates JR 3rd, Chen L, Wu X.,: The interaction of CtIP and Nbs1 connects CDK and ATM to regulate HR-mediated double-strand break repair. PLoS Genet. 2013 Feb;9(2):e1003277. (Link)

Duquette ML, Zhu Q, Taylor ER, Tsay AJ, Shi LZ, Berns MW, McGowan CH.,: CtIP is required to initiate replication-dependent interstrand crosslink repair. PLoS Genet. 2012;8(11):e1003050. (Link)

Lu CS, Truong LN, Aslanian A, Shi LZ, Li Y, Hwang PY, Koh KH, Hunter T, Yates JR 3rd, Berns MW, Wu X.,: The RING finger protein RNF8 ubiquitinates Nbs1 to promote DNA double-strand break repair by homologous recombination. J Biol Chem. 2012 Dec 21;287(52):43984-94. (Link)

Ludington WB, Shi LZ, Zhu Q, Berns MW, Marshall WF.,: Organelle size equalization by a constitutive process. Curr Biol. 2012 Nov 20;22(22):2173-9. (Link)

He J, Shi LZ, Truong LN, Lu CS, Razavian N, Li Y, Negrete A, Shiloach J, Berns MW, Wu X.,: Rad50 zinc-hook is important for the Mre11 complex to bind chromosomal DNA double-strand breaks and initiate various DNA damage responses. J Biol Chem. 2012 Jul 25. (Link)

Wang H, Shao Z, Shi LZ, Hwang PY, Truong LN, Berns MW, Chen DJ, Wu X.,: CtIP protein dimerization is critical for its recruitment to chromosomal DNA double-stranded breaks. J Biol Chem. 2012 Jun 15;287(25):21471-80. (Link)

Harsono MS, Zhu Q, Shi LZ, Duquette M, Berns MW.,: Development of a dual joystick-controlled laser trapping and cutting system for optical micromanipulation of chromosomes inside living cells. J Biophotonics. 2012 Apr 20. (Link)

Wu T, Mohanty S, Gomez-Godinez V, Shi LZ, Liaw LH, Miotke J, Meyer RL, Berns MW.,: Neuronal growth cones respond to laser-induced axonal damage. J R Soc Interface. 2012 Mar 7;9(68):535-47. (Link)

Hyun N, Chandsawangbhuwana C, Zhu Q, Shi LZ, Yang-Wong C, Berns MW.,: Effects of viscosity on sperm motility studied with optical tweezers. J Biomed Opt. 2012 Feb;17(2):025005. (Link)

Chandsawangbhuwana C, Shi LZ, Zhu Q, Alliegro MC, Berns MW.,: High-throughput optofluidic system for the laser microsurgery of oocytes. J Biomed Opt. 2012 Jan;17(1):015001. (Link)

Wu T, Nieminen TA, Mohanty S, Miotke J, Meyer RL, Rubinsztein-Dunlop H., Berns MW.,: A photon-driven micromotor can direct nerve fibre growth. Nature Photonics. 2011 Dec;6:62-67. (Link)

Kong X, Stephens J, Ball AR Jr, Heale JT, Newkirk DA, Berns MW, Yokomori K.,: Condensin I recruitment to base damage-enriched DNA lesions is modulated by PARP1. PLoS One. 2011;6(8):e23548. (Link)

Veitinger T, Riffell JR, Veitinger S, Nascimento JM, Triller A, Chandsawangbhuwana C, Schwane K, Geerts A, Wunder F, Berns MW, Neuhaus EM, Zimmer RK, Spehr M, Hatt H.,: Chemosensory Ca2+ dynamics correlate with diverse behavioral phenotypes in human sperm. J Biol Chem. 2011 May 13;286(19):17311-25. (Link)

Wakida NM, Botvinick EL, Lin J, Berns MW.,: An intact centrosome is required for the maintenance of polarization during directional cell migration. PLoS One. 2010 Dec 23;5(12):e15462. (Link)

Shi LZ, Nascimento J, Botvinick E, Durrant B, Berns MW.,: An interdisciplinary systems approach to study sperm physiology and evolution. Wiley Interdiscip Rev Syst Biol Med. 2010 Jul 26. (Link)

Gomez-Godinez V, Wu T, Sherman AJ, Lee CS, Liaw LH, Zhongsheng Y, Yokomori K, Berns MW.,: Analysis of DNA double-strand break response and chromatin structure in mitosis using laser microirradiation. Nucleic Acids Res. 2010 Oct 4. (Link)

Baker NM, Zeitlin SG, Shi LZ, Shah J, Berns MW.,: Chromosome tips damaged in anaphase inhibit cytokinesis. PLoS One. 2010 Aug 25;5(8):e12398. (Link)

You, Z., L. Z. Shi, Q. Zhu, P. Wu, Y.-W. Zhang, A. Basilio, N. Tonnu, I. M. Verma, M.W. Berns and T. Hunter.,: CtIP links DNA double-strand break sensing to resection. Molecular Cell 36: 954-969, 2009. (Link)

Stephens J, Mohanty SK, Genc S, Kong X, Yokomori K, Berns MW.,: Spatially sculpted laser scissors for study of DNA damage and repair. J Biomed Opt. 2009 Sep-Oct;14(5):054004. (Link)

Kreuter KA, Mahon SB, Mukai DS, Su J, Jung WG, Narula N, Guo S, Wakida N, Raub C, Berns MW, George SC, Chen Z, Brenner M.,: Detection and monitoring of early airway injury effects of half-mustard (2-chloroethylethylsulfide) exposure using high-resolution optical coherence tomography. J Biomed Opt. 2009 Jul-Aug;14(4):044037. (Link)

Zeitlin SG, Baker NM, Chapados BR, Soutoglou E, Wang JY, Berns MW, Cleveland DW.,: Double-strand DNA breaks recruit the centromeric histone CENP-A. Proc Natl Acad Sci U S A. 2009 Sep 15;106(37):15762-7. Epub 2009 Aug 28. (Link)

Yu L, Mohanty S, Zhang J, Genc S, Kim MK, Berns MW, Chen Z.,: Digital holographic microscopy for quantitative cell dynamic evaluation during laser microsurgery. Opt Express. 2009 Jul 6;17(14):12031-8. (Link)

Kong X, Mohanty SK, Stephens J, Heale JT, Gomez-Godinez V, Shi LZ, Kim JS, Yokomori K, Berns MW.,: Comparative analysis of different laser systems to study cellular responses to DNA damage in mammalian cells. Nucleic Acids Res. 2009 May;37(9):e68. Epub 2009 Apr 7. (Link)

Mohanty SK, Mohanty KS, Berns MW.,: Manipulation of mammalian cells using a single-fiber optical microbeam. J Biomed Opt. 2008 Sep; 13(5):054049 (Link)

Yu L, Mohanty S, Liu G, Genc S, Chen Z, Berns MW.,: Quantitative phase evaluation of dynamic changes on cell membrane during laser microsurgery. J Biomed Opt. 2008 Sep-Oct;13(5):050508. (Link)

Mohanty SK, Mohanty KS, Berns MW.,: Organization of microscale objects using a microfabricated optical fiber. Opt Lett. 2008 Sep 15;33(18):2155-7 (Link)

Nascimento JM, Shi LZ, Tam J, Chandsawangbhuwana C, Durrant B, Botvinick EL, Berns MW.,: Comparison of glycolysis and oxidative phosphorylation as energy sources for mammalian sperm motility, using the combination of fluorescence imaging, laser tweezers, and real-time automated tracking and trapping. J Cell Physiol. 2008 Dec;217(3):745-51. (Link)

Mohanty SK, Reinscheid RK, Liu X, Okamura N, Krasieva TB, Berns MW.,: In-depth activation of ChR2 sensitized excitable cells with high spatial resolution using two-photon excitation with near-IR laser microbeam. Biophys J. 2008 Oct;95(8):3916-26 (Link)

Nascimento JM, Shi LZ, Chandsawangbhuwana C, Tam J, Durrant B, Botvinick EL, Berns MW.,: Use of laser tweezers to analyze sperm motility and mitochondrial membrane potential. J Biomed Opt. 2008 Jan-Feb;13(1):014002 (Link)

Shi LZ, Nascimento JM, Chandsawangbhuwana C, Botvinick EL, Berns MW.,: An automatic system to study sperm motility and energetics. Biomed Microdevices. 2008 Feb 26 (Link)

Nascimento JM, Shi LZ, Meyers S, Gagneux P, Loskutoff NM, Botvinick EL, Berns MW.,: The use of optical tweezers to study sperm competition and motility in primates. J R Soc Interface. 2008 Mar 6;5(20):297-302 (Link)

Berns MW, Greulich KO.,: Laser Manipulation of Cells and Tissues. Methods Cell Biology. 2007; Vol 82. (Link)


Berns MW.,: A History of Laser Scissors (Microbeams) . Methods Cell Biol. 2007;82C:1-58. (Link)

Botvinick EL, Shah JV.,: Laser-based measurements in cell biology. Methods Cell Biol. 2007;82:81-109. (Link)

Berns MW.,: Optical Tweezers: Tethers, Wavelengths, and Heat. Methods Cell Biol. 2007;82C:455-466. (Link)

Botvinick EL, Wang Y.,: Laser tweezers in the study of mechanobiology in live cells. Methods Cell Biol. 2007;82:497-523. (Link)

Shao B, Nascimento JM, Shi LZ, Botvinick EL.,: Automated motile cell capture and analysis with optical traps. Methods Cell Biol. 2007;82:601-27. (Link)

Greulich KO, Khodjakov A, Vogt A, Berns MW.,: Sergej stepanovich tschachotin: experimental cytologist and political critic (1883-1973). Methods Cell Biol. 2007;82:723-34. (Link)

Xu J, Van Keymeulen A, Wakida NM, Carlton P, Berns MW, Bourne HR.,: Polarity reveals intrinsic cell chirality. Proc Natl Acad Sci. 2007 May 29;104(22):9296-300. (Link)

Wakida NM, Lee CS, Botvinick ET, Shi LZ, Dvornikov A, Berns MW.,: Laser nanosurgery of single microtubules reveals location-dependent depolymerization rates . J Biomed Opt. 2007 Mar-Apr;12(2):024022. (Link)

Gomez-Godinez V, Wakida NM, Dvornikov AS, Yokomori K, Berns MW.,: Recruitment of DNA damage recognition and repair pathway proteins following near-IR femtosecond laser irradiation of cells. J Biomed Opt. 2007 Mar-Apr;12(2):020505. (Link)

Shao B, Shi LZ, Nascimento JL, Botvinick EL, Ozkan M, Berns MW, Esener SC.,: High-throughput sorting and analysis of human sperm with a ring-shaped laser trap . Biomed Microdevices. Jun;9(3):361-9. (Link)

Shi LZ, Nascimento JM, Berns MW, Botvinick EL.,: Computer-based tracking of single sperm. J Biomed Opt. 2006 Sep-Oct;11(5):054009. (Link)

Nascimento JL, Botvinick EL, Shi LZ, Durrant B, Berns MW.,: Analysis of sperm motility using optical tweezers. J Biomed Opt. 2006 Jul-Aug;11(4):044001. (Link)

Shao B, Esener SC, Nascimento JM, Botvinick EL, Berns MW.,: Dynamically adjustable annular laser trapping based on axicons. Appl Opt. 2006 Sep 1;45(25):6421-8. (Link)

Z Shi L, Nascimento J, Chandsawangbhuwana C, Berns MW, Botvinick EL.,: Real-time automated tracking and trapping system for sperm. Microsc Res Tech. 2006 Jul-Aug;11(4):044001. (Link)

Wang Z, Shah JV, Berns MW, Cleveland DW.,: In vivo quantitative studies of dynamic intracellular processes using fluorescence correlation spectroscopy. Biophys J. 2006 Jul 1;91(1):343-51. (Link)

Botvinick EL, Berns MW.,: Internet-based robotic laser scissors and tweezers microscopy. Microsc Res Tech. 2005 Oct;68(2):65-74. (Link) (News) (Movie)

Wang Y, Botvinick EL, Zhao Y, Berns MW, Usami S, Tsien RY, Chien S.,: Visualizing the mechanical activation of Src. Nature. 2005 Apr 21;434(7036):1040-5. (Link) (News) (Movie1) (Movie2)

Botvinick EL, Venugopalan V, Shah JV, Liaw LH, Berns MW.,: Controlled ablation of microtubules using a picosecond laser. Biophys J. 2004 Dec;87(6):4203-12. (Link)

Berns MW, Krasieva T, Sun CH, Dvornikov A, Rentzepis PM.,: A polarity dependent fluorescence "switch" in live cells. J Photochem Photobiol B. 2004 Jul 19;75(1-2):51-6. (Link)

Shah JV, Botvinick E, Bonday Z, Furnari F, Berns M, Cleveland DW.,: Dynamics of centromere and kinetochore proteins; implications for checkpoint signaling and silencing. Curr Biol. 2004 Jun 8;14(11):942-52. (Link)

Berns MW.,: Laser Scissors and Tweezers. Scientific American. 1998 Apr:62-67. (Link)

Earlier publications